Decolorization of activated carbon in the pharmaceutical process

Activated carbon is black powdery or granular amorphous carbon whose main components are oxygen, hydrogen and other elements in addition to carbon. Activated carbon is a kind of porous carbon with low bulk density and large specific surface area due to the irregular arrangement of microcrystalline carbon in the structure and fine pores between the cross-connections.

Medicinal activated carbon is made of wood, charcoal, etc. as raw materials, produced by two activation processes of chemical method or physical method, and refined into powdered activated carbon with scientific formula after post-treatment. Medicinal activated carbon use: widely used in pharmaceutical industry, fine chemical industry, etc.

The biggest feature of medicinal activated carbon is the fast decolorization speed, strong adsorption capacity, developed internal pore structure and large pores, which can effectively absorb the pigment in the potion and reduce the impurities in the potion without affecting the concentration and medicinal properties of other ingredients in the potion.

The removal of pyrogen by activated carbon in the process of drug preparation is a major problem in the field of biotechnology today. It is particularly important to avoid pyrogen contamination in production and to remove pyrogen. If the purified intermediate or finished product is found to be contaminated by pyrogen, Corresponding measures should be taken to remove, but can not affect the biological activity and yield of the product. Activated carbon was used to adsorb and remove pyrogens in tetanus antitoxin products. The test results showed that the method was quick and easy to operate, had obvious effect on the adsorption of pyrogens in the products and had good repeatability, and further improved the appearance of the products after adsorption.

In the process of heating and leaching of polysaccharides with activated carbon, sucrose will undergo caramelization to form pigments, which will deepen the color of the extract and affect the quality of polysaccharides. There are many ways to remove the color of polysaccharides, and the most commonly used in industry is activated carbon.

The main function of pharmaceutical activated carbon is to remove black, red, brown, yellow, light yellow, pyrogen, etc. Black, brown, and red mean that the removed impurities have a relatively large molecular weight, which requires activated carbon to have more macropores. If it is to remove yellow, light yellow, pyrogen, etc., activated carbon with a larger surface area is required.

When activated carbon decolorizes, it will also dissolve impurities and pollute the product. If customers know their products better, we can choose activated carbon with lower iron content and higher activity, thereby reducing the amount of activated carbon added and reducing iron as much as possible. ion dissolution.